Natural products for dermatitis

Natural products for dermatitis

27 Jun 2019, 16:00 - 16:20

Room 327 Coex
Language:
Korean

The atopic dermatitis (AD) is a chronic inflammatory skin disease. The typical symptoms of AD include skin inflammation, epidermal detachment, scratching behavior, skin barrier dysfunction and dry skin. AD is known to be developed by allergic inflammatory immune response and skin barrier dysfunction. Interleukin-4 (IL-4) and Serine protease inhibitor Kazal type-5 (SPINK5) play crucial roles in inflammatory immune response and skin barrier dysfunction, respectively.

In this study, we investigated the improvement effects of AD and skin barrier function by several natural products (NP) which were shown inhibition of IL-4 and increase of SPINK5 expression in vitro. We examined the effect of NP on atopic AD-like skin lesions in BALB/c, hairless and NC/Nga mice.

NP improved typical symptoms of AD in oxazolone-induced mouse ears, DNCB-induced or dust-mite induced mouse dorsal skin. In correlation with the symptoms, the impaired skin barrier function recovered by NP treatment, as evidenced by the changes in transepidermal water loss (TEWL), skin hydration, and pH. The elevated serum IL-4, immunoglobulin E (IgE) and thymic stromal lymphopoietin (TSLP) levels in AD-induced mouse were decreased by NP treatment. To summarize, NP improved the skin barrier function and suppressed the inflammatory immune response in AD animal models.

In conclusion, we confirmed that applications of NP might be an effective approach for treating AD.

Contributors

  • Su-Nam Kim

    Speaker

    Principal Research Scientist

    Korea Institute of Science and Technology

    2005.10 –  Senior Research Scientist Korea Institute of Science and Technology 2014.4 – Associate Editor of the Korean Society of Ginseng 2016.4 –...

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